THE APPROACHES TO DESIGNING OF NEW GENERATION VACCINES AGAINST THE SHEEP POX DISEASE

Sheep pox disease is a highly contagious viral disease characterized by lesions of the skin. The virus of this disease causes lesions or scarring on the skin, infections of the respiratory tract, damage to skin and wool of the animal, reduction in milk production, weight gain, in wool quality, increases abortion rates [1–3]. It has been reported that the pathogen can be transmitted via air, saliva droplets, flowers strewn, milk and, natural infection transmits by droplet from animal to animal, in some cases insects may play a role as a vector and after the virus infects the organism, viremia occurs and which allows it to spread to the whole body [4]. Currently, sheep pox virus is classified as a potential bioterrorism agent because of its ability to use blood-sucking insects as vectors by United States Department of Agriculture [4, 5]. Furthermore, sheep pox disease is one of the main diseases requiring immediate solution classified as a Group A Disease by the World Organization for Animal Health (OIE). OIE limits the trade of livestock, meat and meat products in countries that have had an epidemic of this disease which can cause severe economic losses [6, 7].