EXPRESSION OF UBIQUITIN SPECIFIC PEPTIDASE GENES IN IRE1 KNOCKDOWN U87 GLIOMA CELLS UPON GLUCOSE DEPRIVATION | Zendy

О. H. Minchenko | Zendy; Olena O. Riabovol | Zendy; Oleh V. Halkin | Zendy; S. V. Danilovskyi | Zendy; Dmytro O. Minchenko | Zendy; О. O. Ratushna | Zendy

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EXPRESSION OF UBIQUITIN SPECIFIC PEPTIDASE GENES IN IRE1 KNOCKDOWN U87 GLIOMA CELLS UPON GLUCOSE DEPRIVATION

Author(s) -

О. H. Minchenko,

Olena O. Riabovol,

Oleh V. Halkin,

S. V. Danilovskyi,

Dmytro O. Minchenko,

О. O. Ratushna

Publication year - 2016

Publication title -

biotechnologia acta

Language(s) - English

Resource type - Journals

eISSN - 2410-776X

pISSN - 2410-7751

DOI - 10.15407/biotech9.05.007

Subject(s) - gene knockdown , ubiquitin , gene , chemistry , biology , microbiology and biotechnology , biochemistry

We have studied the effect of glucose deprivation on the expression of genes encoding for ubiquitin specific peptidases — USP and autophagy related 7 ATG7 in U87 glioma cells in relation to inhibition of inositol requiring enzyme-1 (IRE1). It was shown that glucose deprivation was downregulated the expression of USP1 and USP10 genes and up-regulated USP4 and US P25 genes in control (transfected by empty vector) glioma cells. At the same time, the expression

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