Open AccessNew 4-iminohydantoin sulfamide derivatives with antiviral and anticancer activity
Author(s) -
Yurii Kornii,
О. В. Шаблыкин,
O. V. Shablykina,
В. С. Броварец
Publication year - 2021
Publication title -
ukrainica bioorganica acta
Language(s) - English
Resource type - Journals
eISSN - 1814-9766
pISSN - 1814-9758
DOI - 10.15407/bioorganica2021.01.010
Subject(s) - sulfamide , piperazine , chemistry , stereochemistry , combinatorial chemistry , organic chemistry
A number of sulfamides were obtained by reaction of (5-(dichloromethylene)-2-oxoimidazolidin-4-ylidene)sulfamoyl chloride with anilines, benzylamines, Boc-protected piperazine, methylalylamine, and amino acids methyl esters with primary and secondary amino group. The antiviral and anticancer activity of new derivatives was evaluated. The most effective compounds against Human cytomegalovirus were sulfamides based on anisidine (1b), N-Boc-piperazine (1h), and the derivatives 1n,o with fragments of nipecotic and azetidine-3-carboxylic acids, respectively. Anticancer activity was most significant for sulfamides based on p-methoxybenzylamine (compound 1d), benzylmethylamine (compound 1f), and allylmethylamine (compound 1g).