Is Sex Hormone a Risk Factor of Nociceptive Hypersensitivity in the Context of Cerebrovascular Diseases? | Zendy

Senzhu Bao | Zendy

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Is Sex Hormone a Risk Factor of Nociceptive Hypersensitivity in the Context of Cerebrovascular Diseases?

Author(s) -

Senzhu Bao

Publication year - 2018

Publication title -

science insights

Language(s) - English

Resource type - Journals

eISSN - 2372-8191

pISSN - 2329-5856

DOI - 10.15354/si.18.re079

Subject(s) - hormone , estrogen , medicine , context (archaeology) , epidemiology , hormone replacement therapy (female to male) , stroke (engine) , sex hormone binding globulin , bioinformatics , physiology , testosterone (patch) , biology , androgen , paleontology , mechanical engineering , engineering

Cerebral vessel events have long been considered a leading cause in postmenopausal women with physiological changes in expressing and secreting of sex hormones. Hormone replacement therapy emerged as a supplementary therapeutic strategy under the risk of cerebrovascular accidents and bone loss. Epidemiological and genetic data showed that an interrelationship among hormone and cerebrovascular disorders exist. A battery of animal experiments and clinical observations received different results both positive and negative.. Recent studies still cannot give a once-for-all answer to whichever hormone, estrogen or progesterone overweighs the other in benefits. Here we review and analyze the two hormones’ effects on cerebrovascular diseases and that of associated epidemiological and genetic evidences.■

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