Functional Divergence of Mammalian TFAP2a and TFAP2b Transcription Factors for Bidirectional Sleep Control
Author(s) -
Yang Hu,
Alejandra Korovaichuk,
Mariana Astiz,
Henning Schroeder,
Rezaul Islam,
Jon Jatsu Azkue,
André Fischer,
Henrik Oster,
Henrik Bringmann
Publication year - 2020
Publication title -
genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.792
H-Index - 246
eISSN - 1943-2631
pISSN - 0016-6731
DOI - 10.1534/genetics.120.303533
Subject(s) - biology , genetics , functional divergence , transcription factor , transcription (linguistics) , gene , divergence (linguistics) , control (management) , sleep (system call) , evolutionary biology , computational biology , gene expression , computer science , gene family , artificial intelligence , linguistics , philosophy , operating system
Here, Hu et al. show that AP-2 transcription factors have diverged to take on bidirectional control of sleep in mammals. This is the first instance where a sleep gene is shown to have diversified in evolution
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