Split-QF System for Fine-Tuned Transgene Expression in Drosophila | Zendy

Olena Riabinina | Zendy; Samuel Ver | Zendy; Barry J. Dickson | Zendy; Richard A. Baines | Zendy

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Split-QF System for Fine-Tuned Transgene Expression in Drosophila

Author(s) -

Olena Riabinina,

Samuel Ver,

Barry J. Dickson,

Richard A. Baines

Publication year - 2019

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.119.302034

Subject(s) - biology , repressor lexa , transgene , drosophila (subgenus) , expression (computer science) , genetics , drosophila melanogaster , computational biology , microbiology and biotechnology , gene expression , gene , repressor , computer science , programming language

The Q-system is a binary expression system that works well across species. Here, we report the development and demonstrate the applications of a split-QF system that drives strong expression in Drosophila , is repressible by QS, and is inducible by a small nontoxic molecule (quinic acid). The split-QF system is fully compatible with existing split-GAL4 and split-LexA lines, thus greatly expanding the range of possible advanced intersectional experiments and anatomical, physiological, and behavioral assays in Drosophila , and in other organisms.

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