Neuronal Development in Caenorhabditis elegans Is Regulated by Inhibition of an MLK MAP Kinase Pathway | Zendy

Scott T. Baker | Zendy; Shane M. Turgeon | Zendy; Erik D. Tulgren | Zendy; Jeanne Wigant | Zendy; Omeed Rahimi | Zendy; Karla J. Opperman | Zendy; Brock Grill | Zendy

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Neuronal Development in Caenorhabditis elegans Is Regulated by Inhibition of an MLK MAP Kinase Pathway

Author(s) -

Scott T. Baker,

Shane M. Turgeon,

Erik D. Tulgren,

Jeanne Wigant,

Omeed Rahimi,

Karla J. Opperman,

Brock Grill

Publication year - 2014

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.114.170589

Subject(s) - caenorhabditis elegans , biology , kinase , function (biology) , microbiology and biotechnology , phosphatase , genetics , mutation , loss function , gene , phosphorylation , phenotype

We show that loss-of-function mutations in kinases of the MLK-1 pathway (mlk-1, mek-1, and kgb-1/jnk) function cell-autonomously in neurons to suppress defects in synapse formation and axon termination caused by rpm-1 loss of function. Our genetic analysis also suggests that the phosphatase PPM-1, like RPM-1, is a potential inhibitor of kinases in the MLK-1 pathway.

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