Differential Regulation of Germline Apoptosis in Response to Meiotic Checkpoint Activation | Zendy

Alice Ye | Zendy; James Matthew Ragle | Zendy; Barbara Conradt | Zendy; Needhi Bhalla | Zendy

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Differential Regulation of Germline Apoptosis in Response to Meiotic Checkpoint Activation

Author(s) -

Alice Ye,

James Matthew Ragle,

Barbara Conradt,

Needhi Bhalla

Publication year - 2014

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.114.170241

Subject(s) - germline , biology , caenorhabditis elegans , meiosis , g2 m dna damage checkpoint , genetics , dna damage , checkpoint kinase 2 , microbiology and biotechnology , apoptosis , chek1 , dna , cell cycle checkpoint , gene , cell cycle

In Caenorhabditis elegans, germline apoptosis is promoted by egl-1 and ced-13 in response to meiotic checkpoint activation. We report that the requirement for these two factors depends on which checkpoints are active. We also identify a regulatory region of egl-1 required to inhibit germline apoptosis in response to DNA damage incurred during meiotic recombination.

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