Mechanisms and Regulation of Mitotic Recombination in Saccharomyces cerevisiae | Zendy

Lorraine S. Symington | Zendy; Rodney Rothstein | Zendy; Michael Lisby | Zendy

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Mechanisms and Regulation of Mitotic Recombination in Saccharomyces cerevisiae

Author(s) -

Lorraine S. Symington,

Rodney Rothstein,

Michael Lisby

Publication year - 2014

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.114.166140

Subject(s) - biology , saccharomyces cerevisiae , mitotic crossover , homologous recombination , genetics , mitosis , chromosome segregation , meiosis , genetic recombination , homologous chromosome , flp frt recombination , gene , genome , dna replication , dna , chromosome , cell division , recombination , cell

Homology-dependent exchange of genetic information between DNA molecules has a profound impact on the maintenance of genome integrity by facilitating error-free DNA repair, replication, and chromosome segregation during cell division as well as programmed cell developmental events. This chapter will focus on homologous mitotic recombination in budding yeast Saccharomyces cerevisiae. However, there is an important link between mitotic and meiotic recombination (covered in the forthcoming chapter by Hunter et al. 2015) and many of the functions are evolutionarily conserved. Here we will discuss several models that have been proposed to explain the mechanism of mitotic recombination, the genes and proteins involved in various pathways, the genetic and physical assays used to discover and study these genes, and the roles of many of these proteins inside the cell.

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