A Novel Cell Death Gene Acts to Repair Patterning Defects in Drosophila melanogaster | Zendy

Kentaro M. Tanaka | Zendy; Aya Takahashi | Zendy; Naoyuki Fuse | Zendy; Toshiyuki TakanoShimizu | Zendy

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A Novel Cell Death Gene Acts to Repair Patterning Defects in Drosophila melanogaster

Author(s) -

Kentaro M. Tanaka,

Aya Takahashi,

Naoyuki Fuse,

Toshiyuki TakanoShimizu

Publication year - 2014

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.114.163337

Subject(s) - drosophila melanogaster , biology , genetics , gene , drosophila (subgenus) , drosophilidae , programmed cell death , evolutionary biology , apoptosis

Cell death is a mechanism utilized by organisms to eliminate excess cells during development. Here, we describe a novel regulator of caspase-independent cell death, Mabiki (Mabi), that is involved in the repair of the head patterning defects caused by extra copies of bicoid in Drosophila melanogaster. Mabiki functions together with caspase-dependent cell death mechanisms to provide robustness during development.

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