Heterochromatin Position Effects on Circularized Sex Chromosomes Cause Filicidal Embryonic Lethality in Drosophila melanogaster | Zendy

Patrick M. Ferree | Zendy; Karina Gomez | Zendy; Peter Rominger | Zendy; D.R. Howard | Zendy; Hannah Kornfeld | Zendy; Daniel A. Barbash | Zendy

Open Access

Heterochromatin Position Effects on Circularized Sex Chromosomes Cause Filicidal Embryonic Lethality in Drosophila melanogaster

Author(s) -

Patrick M. Ferree,

Karina Gomez,

Peter Rominger,

D.R. Howard,

Hannah Kornfeld,

Daniel A. Barbash

Publication year - 2014

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.113.161075

Subject(s) - biology , drosophila melanogaster , heterochromatin , genetics , lethality , synthetic lethality , chromosome , phenotype , drosophila (subgenus) , anaphase , dna , gene , dna repair

Some circularized X-Y chromosomes in Drosophila melanogaster are mitotically unstable and induce early embryonic lethality, but the genetic basis is unknown. Our experiments suggest that a large region of X-linked satellite DNA causes anaphase bridges and lethality when placed into a new heterochromatic environment within certain circularized X-Y chromosomes. These results reveal that repetitive sequences can be incompatible with one another in cis. The lethal phenotype also bears a remarkable resemblance to a case of interspecific hybrid lethality.

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