The mRNA Decay Pathway Regulates the Expression of the Flo11 Adhesin and Biofilm Formation inSaccharomyces cerevisiae | Zendy

Tricia L. Lo | Zendy; Yue Qu | Zendy; Nathalie Uwamahoro | Zendy; Tara Quenault | Zendy; Traude H. Beilharz | Zendy; Ana Traven | Zendy

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The mRNA Decay Pathway Regulates the Expression of the Flo11 Adhesin and Biofilm Formation inSaccharomyces cerevisiae

Author(s) -

Tricia L. Lo,

Yue Qu,

Nathalie Uwamahoro,

Tara Quenault,

Traude H. Beilharz,

Ana Traven

Publication year - 2012

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.112.141432

Subject(s) - repressor , biology , exonuclease , saccharomyces cerevisiae , transcription (linguistics) , messenger rna , microbiology and biotechnology , gene , regulation of gene expression , gene expression , psychological repression , genetics , polymerase , linguistics , philosophy

Regulation of the FLO11 adhesin is a model for gene expression control by extracellular signals and developmental switches. We establish that the major mRNA decay pathway regulates FLO11 expression. mRNA deadenylation of transcriptional repressors of FLO11 by the exonuclease Ccr4 keeps their levels low, thereby allowing FLO11 transcription.

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