Diverse Tumor Pathology due to Distinctive Patterns of JAK/STAT Pathway Activation Caused by Different Drosophila polyhomeotic Alleles | Zendy

Siqian Feng | Zendy; Steffi Thomas | Zendy; Jian Wang | Zendy

Open Access

Diverse Tumor Pathology due to Distinctive Patterns of JAK/STAT Pathway Activation Caused by Different Drosophila polyhomeotic Alleles

Author(s) -

Siqian Feng,

Steffi Thomas,

Jian Wang

Publication year - 2011

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.111.135442

Subject(s) - biology , allele , phenotype , null allele , imaginal disc , genetics , gene , mutant , drosophila (subgenus) , stat , secretion , mutation , stat3 , biochemistry

Drosophila polyhomeotic (ph) is one of the important polycomb group genes that is linked to human cancer. In the mosaic eye imaginal discs, while ph(del), a null allele, causes only non-autonomous overgrowth, ph(505), a hypomorphic allele, causes both autonomous and non-autonomous overgrowth. These allele-specific phenotypes stem from the different sensitivities of ph mutant cells to the Upd homologs that they secrete.

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