Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control | Zendy

Robbie Loewith | Zendy; Michael N. Hall | Zendy

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Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control

Author(s) -

Robbie Loewith,

Michael N. Hall

Publication year - 2011

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.111.133363

Subject(s) - tor signaling , biology , saccharomyces cerevisiae , signal transduction , function (biology) , computational biology , genetics , nutrient sensing , yeast , kinase , microbiology and biotechnology , caenorhabditis elegans , drug discovery , bioinformatics , gene

TOR (Target Of Rapamycin) is a highly conserved protein kinase that is important in both fundamental and clinical biology. In fundamental biology, TOR is a nutrient-sensitive, central controller of cell growth and aging. In clinical biology, TOR is implicated in many diseases and is the target of the drug rapamycin used in three different therapeutic areas. The yeast Saccharomyces cerevisiae has played a prominent role in both the discovery of TOR and the elucidation of its function. Here we review the TOR signaling network in S. cerevisiae.

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