emb-1 Encodes the APC16 Subunit of the Caenorhabditis elegans Anaphase-Promoting Complex | Zendy

Diane C. Shakes | Zendy; Anna K. Allen | Zendy; Kelsey M Albert | Zendy; Andy Golden | Zendy

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emb-1 Encodes the APC16 Subunit of the Caenorhabditis elegans Anaphase-Promoting Complex

Author(s) -

Diane C. Shakes,

Anna K. Allen,

Kelsey M Albert,

Andy Golden

Publication year - 2011

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.111.131714

Subject(s) - biology , caenorhabditis elegans , anaphase , mutant , germline , genetics , anaphase promoting complex , mitosis , phenotype , microbiology and biotechnology , protein subunit , meiosis , chromosome segregation , metaphase , chromosome , gene

In the nematode Caenorhabditis elegans, temperature-sensitive mutants of emb-1 arrest as one-cell embryos in metaphase of meiosis I in a manner that is indistinguishable from embryos that have been depleted of known subunits of the anaphase-promoting complex or cyclosome (APC/C). Here we show that the emb-1 phenotype is enhanced in double mutant combinations with known APC/C subunits and suppressed in double mutant combinations with known APC/C suppressors. In addition to its meiotic function, emb-1 is required for mitotic proliferation of the germline. These studies reveal that emb-1 encodes K10D2.4, a homolog of the small, recently discovered APC/C subunit, APC16.

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