Genome-Wide Epigenetic Perturbation Jump-Starts Patterns of Heritable Variation Found in Nature | Zendy

Fabrice Roux | Zendy; Maria ColoméTatché | Zendy; Cécile Edelist | Zendy; René Wardenaar | Zendy; Philippe Guerche | Zendy; Frédéric Hospital | Zendy; Vincent Colot | Zendy; Ritsert C. Jansen | Zendy; Frank Johannes | Zendy

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Genome-Wide Epigenetic Perturbation Jump-Starts Patterns of Heritable Variation Found in Nature

Author(s) -

Fabrice Roux,

Maria ColoméTatché,

Cécile Edelist,

René Wardenaar,

Philippe Guerche,

Frédéric Hospital,

Vincent Colot,

Ritsert C. Jansen,

Frank Johannes

Publication year - 2011

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.111.128744

Subject(s) - biology , heritability , epigenetics , dna methylation , genetics , evolutionary biology , natural selection , genetic architecture , genome , phenotype , genetic variation , adaptation (eye) , gene , selection (genetic algorithm) , gene expression , artificial intelligence , neuroscience , computer science

We extensively phenotyped 6000 Arabidopsis plants with experimentally perturbed DNA methylomes as well as a diverse panel of natural accessions in a common garden. We found that alterations in DNA methylation not only caused heritable phenotypic diversity but also produced heritability patterns closely resembling those of the natural accessions. Our findings indicate that epigenetically induced and naturally occurring variation in complex traits share part of their polygenic architecture and may offer complementary adaptation routes in ecological settings.

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