Genetic Evidence That DNA Methyltransferase DRM2 Has a Direct Catalytic Role in RNA-Directed DNA Methylation in Arabidopsis thaliana | Zendy

Ulf Naumann | Zendy; Lucia Daxinger | Zendy; Tatsuo Kanno | Zendy; ChangHo Eun | Zendy; Quan Long | Zendy; Zdravko J. Lorković | Zendy; Marjori Matzke | Zendy; A. J. M. Matzke | Zendy

Open Access

Genetic Evidence That DNA Methyltransferase DRM2 Has a Direct Catalytic Role in RNA-Directed DNA Methylation in Arabidopsis thaliana

Author(s) -

Ulf Naumann,

Lucia Daxinger,

Tatsuo Kanno,

ChangHo Eun,

Quan Long,

Zdravko J. Lorković,

Marjori Matzke,

A. J. M. Matzke

Publication year - 2011

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.110.125401

Subject(s) - biology , methyltransferase , rna directed dna methylation , arabidopsis thaliana , genetics , dna methylation , epigenetics , arabidopsis , methylation , mutant , rna , dna , dna methyltransferase , mutation , gene , gene expression

RNA-directed DNA methylation (RdDM) is a small RNA-mediated epigenetic modification in plants. We report here the identification of DOMAINS REARRANGED METHYLTRANSFERASE 2 (DRM2) in a forward screen for mutants defective in RdDM in Arabidopsis thaliana. The finding of a mutation in the presumptive active site argues in favor of direct catalytic activity for DRM2.

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