Insulin/Insulin-Like Growth Factor Signaling Controls Non-Dauer Developmental Speed in the Nematode Caenorhabditis elegans | Zendy

AnneFrançoise Ruaud | Zendy; Iskra Katic | Zendy; JeanLouis Bessereau | Zendy

Open Access

Insulin/Insulin-Like Growth Factor Signaling Controls Non-Dauer Developmental Speed in the Nematode Caenorhabditis elegans

Author(s) -

AnneFrançoise Ruaud,

Iskra Katic,

JeanLouis Bessereau

Publication year - 2010

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.110.123323

Subject(s) - biology , caenorhabditis elegans , insulin , genetics , insulin receptor , nematode , insulin like growth factor , growth factor , signal transduction , microbiology and biotechnology , endocrinology , gene , insulin resistance , receptor , ecology

Identified as a major pathway controlling entry in the facultative dauer diapause stage, the DAF-2/Insulin receptor (InsR) signaling acts in multiple developmental and physiological regulation events in Caenorhabditis elegans. Here we identified a role of the insulin-like pathway in controlling developmental speed during the C. elegans second larval stage. This role relies on the canonical DAF-16/FOXO-dependent branch of the insulin-like signaling and is largely independent of dauer formation. Our studies provide further evidence for broad conservation of insulin/insulin-like growth factor (IGF) functions in developmental speed control.

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