A Strategy for Direct Mapping and Identification of Mutations by Whole-Genome Sequencing | Zendy

Steven Zuryn | Zendy; Stéphanie Le Gras | Zendy; Karine Jamet | Zendy; Sophie Jarriault | Zendy

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A Strategy for Direct Mapping and Identification of Mutations by Whole-Genome Sequencing

Author(s) -

Steven Zuryn,

Stéphanie Le Gras,

Karine Jamet,

Sophie Jarriault

Publication year - 2010

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.110.119230

Subject(s) - identification (biology) , computational biology , whole genome sequencing , biology , genetics , isolation (microbiology) , genome , dna sequencing , mutation , gene , bioinformatics , botany

Mutant screens have proven powerful for genetic dissection of a myriad of biological processes, but subsequent identification and isolation of the causative mutations are usually complex and time consuming. We have made the process easier by establishing a novel strategy that employs whole-genome sequencing to simultaneously map and identify mutations without the need for any prior genetic mapping.

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