The Nucleosome Remodeling Factor ISWI Functionally Interacts With an Evolutionarily Conserved Network of Cellular Factors | Zendy

Walter Arancio | Zendy; Maria Cristina Onorati | Zendy; Giosalba Burgio | Zendy; M Collesano | Zendy; A Ingrassia | Zendy; Swonild Ilenia Genovese | Zendy; Manolis Fanto | Zendy; Davide Corona | Zendy

Open Access

The Nucleosome Remodeling Factor ISWI Functionally Interacts With an Evolutionarily Conserved Network of Cellular Factors

Author(s) -

Walter Arancio,

Maria Cristina Onorati,

Giosalba Burgio,

M Collesano,

A Ingrassia,

Swonild Ilenia Genovese,

Manolis Fanto,

Davide Corona

Publication year - 2010

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.110.114256

Subject(s) - biology , transcription factor , drosophila melanogaster , genetics , chromatin remodeling , chromatin , conserved sequence , microbiology and biotechnology , dna , gene , peptide sequence

ISWI is an evolutionarily conserved ATP-dependent chromatin remodeling factor playing central roles in DNA replication, RNA transcription, and chromosome organization. The variety of biological functions dependent on ISWI suggests that its activity could be highly regulated. Our group has previously isolated and characterized new cellular activities that positively regulate ISWI in Drosophila melanogaster. To identify factors that antagonize ISWI activity we developed a novel in vivo eye-based assay to screen for genetic suppressors of ISWI. Our screen revealed that ISWI interacts with an evolutionarily conserved network of cellular and nuclear factors that escaped previous genetic and biochemical analyses.

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