Genetic Testing of the Hypothesis That Hybrid Male Lethality Results From a Failure in Dosage Compensation | Zendy

Daniel A. Barbash | Zendy

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Genetic Testing of the Hypothesis That Hybrid Male Lethality Results From a Failure in Dosage Compensation

Author(s) -

Daniel A. Barbash

Publication year - 2009

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.109.108100

Subject(s) - drosophila melanogaster , dosage compensation , biology , lethality , melanogaster , genetics , compensation (psychology) , x chromosome , chromosome , gene , gene dosage , psychology , gene expression , psychoanalysis

Several recent studies have suggested that F(1) hybrid male lethality in crosses between Drosophila melanogaster and D. simulans is due to a failure in dosage compensation, caused by incompatibilities between D. simulans dosage compensation proteins and the D. melanogaster X chromosome. Contrary to the predictions of this hypothesis, mutations in four essential D. melanogaster dosage compensation genes are shown here to moderately increase rather than decrease hybrid male viability.

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