Ectopic Overproduction of a Sporulation-Specific Transcription Factor Induces Assembly of Prespore-Like Membranous Compartments in Vegetative Cells of Fission Yeast | Zendy

Yukiko Nakase | Zendy; Aiko Hirata | Zendy; Chikashi Shimoda | Zendy; Taro Nakamura | Zendy

Open Access

Ectopic Overproduction of a Sporulation-Specific Transcription Factor Induces Assembly of Prespore-Like Membranous Compartments in Vegetative Cells of Fission Yeast

Author(s) -

Yukiko Nakase,

Aiko Hirata,

Chikashi Shimoda,

Taro Nakamura

Publication year - 2009

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.109.106906

Subject(s) - biology , ectopic expression , transcription factor , microbiology and biotechnology , yeast , fission , transcription (linguistics) , overproduction , genetics , gene , linguistics , philosophy , physics , quantum mechanics , neutron

Mei4 is a key sporulation-specific transcription factor in fission yeast. Ectopic expression of Mei4 in vegetative cells caused formation of nucleated membranous compartments, which shared common features with normal forespore membranes, thereby perturbing nuclear division. These results suggest why expression of development-specific transcription factors must be strictly controlled.

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