Precise Gene-Dose Alleles for Chemical Genetics | Zendy

Zhun Yan | Zendy; Nicolas M. Berbenetz | Zendy; Guri Giaever | Zendy; Corey Nislow | Zendy

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Precise Gene-Dose Alleles for Chemical Genetics

Author(s) -

Zhun Yan,

Nicolas M. Berbenetz,

Guri Giaever,

Corey Nislow

Publication year - 2009

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.109.103036

Subject(s) - allele , biology , genetics , gene , phenotype , saccharomyces cerevisiae , gene dosage , function (biology) , computational biology , gene expression

Modulating gene dose is an effective way to alter protein levels and modify phenotypes to understand gene function. In addition, combining gene-dose alleles with chemical perturbation can provide insight into drug-gene interactions. Here, we present a strategy that combines diverse loss-of-function alleles to systematically modulate gene dose in Saccharomyces cerevisiae. The generated gene dosage allele set expands the genetic toolkit for uncovering novel phenotypes.

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