Genetic Architecture of Tameness in a Rat Model of Animal Domestication | Zendy

Frank W. Albert | Zendy; Örjan Carlborg | Zendy; Irina Z. Plyusnina | Zendy; François Besnier | Zendy; Daniela Hedwig | Zendy; Susann Lautenschläger | Zendy; Doreen Lorenz | Zendy; Jenny McIntosh | Zendy; Christof Neumann | Zendy; Henning Richter | Zendy; Claudia Zeising | Zendy; R. V. Kozhemyakina | Zendy; Olesya Shchepina | Zendy; Jürgen Kratzsch | Zendy; Lyudmila N. Trut | Zendy; Daniel Teupser | Zendy; Joachim Thiery | Zendy; Torsten Schöneberg | Zendy; Leif Andersson | Zendy; Svante Pääbo | Zendy

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Genetic Architecture of Tameness in a Rat Model of Animal Domestication

Author(s) -

Frank W. Albert,

Örjan Carlborg,

Irina Z. Plyusnina,

François Besnier,

Daniela Hedwig,

Susann Lautenschläger,

Doreen Lorenz,

Jenny McIntosh,

Christof Neumann,

Henning Richter,

Claudia Zeising,

R. V. Kozhemyakina,

Olesya Shchepina,

Jürgen Kratzsch,

Lyudmila N. Trut,

Daniel Teupser,

Joachim Thiery,

Torsten Schöneberg,

Leif Andersson,

Svante Pääbo

Publication year - 2009

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.109.102186

Subject(s) - biology , quantitative trait locus , genetic architecture , epistasis , aggression , genetics , population , gene , allele , locus (genetics) , domestication , developmental psychology , psychology , demography , sociology

A common feature of domestic animals is tameness-i.e., they tolerate and are unafraid of human presence and handling. To gain insight into the genetic basis of tameness and aggression, we studied an intercross between two lines of rats (Rattus norvegicus) selected over >60 generations for increased tameness and increased aggression against humans, respectively. We measured 45 traits, including tameness and aggression, anxiety-related traits, organ weights, and levels of serum components in >700 rats from an intercross population. Using 201 genetic markers, we identified two significant quantitative trait loci (QTL) for tameness. These loci overlap with QTL for adrenal gland weight and for anxiety-related traits and are part of a five-locus epistatic network influencing tameness. An additional QTL influences the occurrence of white coat spots, but shows no significant effect on tameness. The loci described here are important starting points for finding the genes that cause tameness in these rats and potentially in domestic animals in general.

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