Stem Cells, Their Niches and the Systemic Environment: An Aging Network | Zendy

Daniela DrummondBarbosa | Zendy

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Stem Cells, Their Niches and the Systemic Environment: An Aging Network

Author(s) -

Daniela DrummondBarbosa

Publication year - 2008

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.108.098244

Subject(s) - biology , stem cell , niche , ecological niche , stem cell niche , neuroscience , microbiology and biotechnology , evolutionary biology , genetics , ecology , progenitor cell , habitat

Stem cells have a fascinating biology and offer great prospects for therapeutic applications, stimulating intense research on what controls their properties and behavior. Although there have been significant advances in our understanding of how local microenvironments, or niches, control the maintenance and activity of stem cells, it is much less well understood how stem cells sense and respond to variable external, physiological, or tissue environments. This review focuses on the multidirectional interactions among stem cells, niches, tissues, and the systemic environment and on potential ideas for how changes in this network of communication may relate to the aging process.

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