Membrane Bound Axin Is Sufficient for Wingless Signaling in Drosophila Embryos | Zendy

Nicholas S. Tolwinski | Zendy

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Membrane Bound Axin Is Sufficient for Wingless Signaling in Drosophila Embryos

Author(s) -

Nicholas S. Tolwinski

Publication year - 2009

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.108.098236

Subject(s) - biology , drosophila melanogaster , microbiology and biotechnology , signal transduction , nuclear localization sequence , cytoplasm , drosophila (subgenus) , genetics , zebrafish , nuclear export signal , wnt signaling pathway , armadillo , cell nucleus , gene

The Wingless signaling pathway controls various developmental processes in both vertebrates and invertebrates. Here I probe the requirement for nuclear localization of APC2 and Axin in the Wg signal transduction pathway during embryonic development of Drosophila melanogaster. I find that nuclear localization of APC2 appears to be required, but Axin can block signaling when tethered to the membrane. These results support the model where Axin regulates Armadillo localization and activity in the cytoplasm.

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