A G2-Phase Microtubule-Damage Response in Fission Yeast | Zendy

Fernando R. Balestra | Zendy; Juan Jiménez | Zendy

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A G2-Phase Microtubule-Damage Response in Fission Yeast

Author(s) -

Fernando R. Balestra,

Juan Jiménez

Publication year - 2008

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.108.094797

Subject(s) - microbiology and biotechnology , mitosis , biology , spindle pole body , microtubule , spindle apparatus , spindle checkpoint , mitotic exit , interphase , sister chromatids , kinetochore , wee1 , cell cycle , cell division , genetics , cyclin dependent kinase 1 , cell , chromosome , gene

Microtubules assume a variety of structures throughout the different stages of the cell cycle. Ensuring the correct assembly of such structures is essential to guarantee cell division. During mitosis, it is well established that the spindle assembly checkpoint monitors the correct attachment of sister chromatids to the mitotic spindle. However, the role that microtubule cytoskeleton integrity plays for cell-cycle progression during interphase is uncertain. Here we describe the existence of a mechanism, independent of the mitotic checkpoint, that delays entry into mitosis in response to G(2)-phase microtubule damage. Disassembly of the G(2)-phase microtubule array leads to the stabilization of the universal mitotic inhibitor Wee1, thus actively delaying entry into mitosis via inhibitory Cdc2 Tyr15 phosphorylation.

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