A Fundamental Relationship Between Genotype Frequencies and Fitnesses | Zendy

Joseph Lachance | Zendy

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A Fundamental Relationship Between Genotype Frequencies and Fitnesses

Author(s) -

Joseph Lachance

Publication year - 2008

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.108.093518

Subject(s) - heterozygote advantage , biology , allele frequency , genotype , geometric mean , population , genetics , allele , genotype frequency , statistics , mathematics , gene , demography , sociology

The set of possible postselection genotype frequencies in an infinite, randomly mating population is found. Geometric mean heterozygote frequency divided by geometric mean homozygote frequency equals two times the geometric mean heterozygote fitness divided by geometric mean homozygote fitness. The ratio of genotype frequencies provides a measure of genetic variation that is independent of allele frequencies. When this ratio does not equal two, either selection or population structure is present. Within-population HapMap data show population-specific patterns, while pooled data show an excess of homozygotes.

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