HPL-2/HP1 Prevents Inappropriate Vulval Induction in Caenorhabditis elegans by Acting in Both HYP7 and Vulval Precursor Cells | Zendy

Sonia Schott | Zendy; Fabien Ramos | Zendy; Vincent Coustham | Zendy; Francesca Palladino | Zendy

Open Access

HPL-2/HP1 Prevents Inappropriate Vulval Induction in Caenorhabditis elegans by Acting in Both HYP7 and Vulval Precursor Cells

Author(s) -

Sonia Schott,

Fabien Ramos,

Vincent Coustham,

Francesca Palladino

Publication year - 2008

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.108.089276

Subject(s) - caenorhabditis elegans , biology , hox gene , syncytium , ectopic expression , genetics , gene , precursor cell , caenorhabditis , microbiology and biotechnology , inducer , cell , gene expression

A current model for Caenorhabditis elegans vulval cell fate specification is that SynMuv genes act redundantly in the hyp7 hypodermal syncytium to repress the LIN-3/EGF inducer and prevent ectopic vulval induction of vulva precursor cells (VPCs). Here we show that the SynMuv gene hpl-2/HP1 has an additional function in VPCs, where it may act through target genes including LIN-39/Hox.

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