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Although susceptibility to scrapie is largely controlled by the PRNP gene, we have searched for additional genomic regions that affect scrapie incubation time in sheep, using two half-sib families with a susceptible PRNP genotype and naturally infected by scrapie. Quantitative trait loci were detected on OAR6 and OAR18.

Identification of New Quantitative Trait Loci (Other Than the PRNP Gene) Modulating the Scrapie Incubation Period in Sheep