Functional Characterization of the Drosophila Hmt4-20/Suv4-20 Histone Methyltransferase | Zendy

Ayako Sakaguchi | Zendy; Dmitry Karachentsev | Zendy; Mansha SethPasricha | Zendy; Marina Druzhinina | Zendy; Ruth Steward | Zendy

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Functional Characterization of the Drosophila Hmt4-20/Suv4-20 Histone Methyltransferase

Author(s) -

Ayako Sakaguchi,

Dmitry Karachentsev,

Mansha SethPasricha,

Marina Druzhinina,

Ruth Steward

Publication year - 2008

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.108.087650

Subject(s) - biology , histone methyltransferase , histone h4 , genetics , histone , histone h2a , mutant , drosophila melanogaster , methyltransferase , position effect , histone code , mutation , gene , methylation , nucleosome

Di- and trimethylation of histone H4 lysine20 (H4K20) are thought to play an important role in controlling gene expression in vertebrates and in Drosophila. By inducing a null mutation in Drosophila Suv4-20, we show that it encodes the histone H4 lysine20 di- and trimethyltransferase. In Suv4-20 mutants, the H4K20 di- and trimethyl marks are strongly reduced or absent, and the monomethyl mark is significantly increased. We find that even with this biochemical function, Suv4-20 is not required for survival and does not control position-effect variegation (PEV).

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