The Anomalous Effects of Biased Mutation Revisited: Mean–Optimum Deviation and Apparent Directional Selection Under Stabilizing Selection | Zendy

XuSheng Zhang | Zendy; William G. Hill | Zendy

Open Access

The Anomalous Effects of Biased Mutation Revisited: Mean–Optimum Deviation and Apparent Directional Selection Under Stabilizing Selection

Author(s) -

XuSheng Zhang,

William G. Hill

Publication year - 2008

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.107.083428

Subject(s) - selection (genetic algorithm) , biology , pleiotropy , population mean , mutation , directional selection , stabilizing selection , genetics , population , statistics , standard deviation , genetic drift , evolutionary biology , genetic variation , mathematics , phenotype , computer science , gene , demography , artificial intelligence , estimator , sociology

Empirical evidence indicates that the distribution of the effects of mutations on quantitative traits is not symmetric about zero. Under stabilizing selection in infinite populations with normally distributed mutant effects having a nonzero mean, Waxman and Peck showed that the deviation of the population mean from the optimum is expected to be small. We show by simulation that genetic drift, leptokurtosis of mutational effects, and pleiotropy can increase the mean-optimum deviation greatly, however, and that the apparent directional selection thereby caused can be substantial.

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