Synthetic Lethal Interactions Identify Phenotypic “Interologs” of the Spindle Assembly Checkpoint Components | Zendy

Maja TarailoGraovac | Zendy; Sanja Tarailo | Zendy; Ann M. Rose | Zendy

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Synthetic Lethal Interactions Identify Phenotypic “Interologs” of the Spindle Assembly Checkpoint Components

Author(s) -

Maja TarailoGraovac,

Sanja Tarailo,

Ann M. Rose

Publication year - 2007

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.107.080408

Subject(s) - biology , caenorhabditis elegans , rna interference , phenotype , genetics , genetic screen , spindle checkpoint , mutant , enhancer , synthetic lethality , mutation , function (biology) , microbiology and biotechnology , kinetochore , gene , chromosome , transcription factor , rna

Here, we report genetic interactions with mdf-1(gk2)/MAD1 in Caenorhabditis elegans. Nine are evolutionarily conserved or phenotypic “interologs” and two are novel enhancers, hcp-1 and bub-3. We show that HCP-1 and HCP-2, the two CENP-F-related proteins, recently implicated in the spindle assembly checkpoint (SAC) function, do not have identical functions, since hcp-1(RNAi), but not hcp-2(RNAi), enhances the lethality of the SAC mutants.

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