Investigations of CHD1 Function in Transcription and Development of Drosophila melanogaster | Zendy

Ivy E. McDaniel | Zendy; Jennifer M Lee | Zendy; Matthew S Berger | Zendy; Cori K Hanagami | Zendy; Jennifer A. Armstrong | Zendy

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Investigations of CHD1 Function in Transcription and Development of Drosophila melanogaster

Author(s) -

Ivy E. McDaniel,

Jennifer M Lee,

Matthew S Berger,

Cori K Hanagami,

Jennifer A. Armstrong

Publication year - 2008

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.107.079038

Subject(s) - biology , chromatin , genetics , polytene chromosome , drosophila melanogaster , rna polymerase ii , transcription (linguistics) , microbiology and biotechnology , mutant , chromatin remodeling , gene , promoter , gene expression , linguistics , philosophy

In this report we describe chd1 mutant alleles and show that the CHD1 chromatin-remodeling factor is important for wing development and fertility. While CHD1 colocalizes with elongating RNA polymerase II (Pol II) on polytene chromosomes, elongating Pol II can persist on chromatin in the absence of CHD1. These results clarify the roles of chromatin remodelers in transcription and provide novel insights into CHD1 function.

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