An Accurate Model for Genetic Hitchhiking | Zendy

Anders Eriksson | Zendy; Pontus Fernström | Zendy; B. Mehlig | Zendy; Serik Sagitov | Zendy

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An Accurate Model for Genetic Hitchhiking

Author(s) -

Anders Eriksson,

Pontus Fernström,

B. Mehlig,

Serik Sagitov

Publication year - 2008

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.107.076018

Subject(s) - biology , selection (genetic algorithm) , population , allele frequency , selective sweep , simple (philosophy) , neutral mutation , statistical physics , allele , genetics , evolutionary biology , physics , gene , computer science , artificial intelligence , philosophy , demography , epistemology , sociology , haplotype

We suggest a simple deterministic approximation for the growth of the favored-allele frequency during a selective sweep. Using this approximation we introduce an accurate model for genetic hitchhiking. Only when Ns<10 (N is the population size and s denotes the selection coefficient) are discrepancies between our approximation and direct numerical simulations of a Moran model notable. Our model describes the gene genealogies of a contiguous segment of neutral loci close to the selected one, and it does not assume that the selective sweep happens instantaneously. This enables us to compute SNP distributions on the neutral segment without bias.

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