A Role forCaenorhabditis elegansChromatin-Associated Protein HIM-17 in the Proliferationvs. Meiotic Entry Decision | Zendy

Jessica B. Bessler | Zendy; Kirthi C. Reddy | Zendy; Michiko Hayashi | Zendy; Jonathan Hodgkin | Zendy; Anne M. Villeneuve | Zendy

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A Role forCaenorhabditis elegansChromatin-Associated Protein HIM-17 in the Proliferationvs. Meiotic Entry Decision

Author(s) -

Jessica B. Bessler,

Kirthi C. Reddy,

Michiko Hayashi,

Jonathan Hodgkin,

Anne M. Villeneuve

Publication year - 2007

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.107.070987

Subject(s) - biology , germline , meiosis , caenorhabditis elegans , chromatin , prophase , genetics , mutant , microbiology and biotechnology , phenotype , gene

Chromatin-associated protein HIM-17 was previously shown to function in the chromosomal events of meiotic prophase. Here we report an additional role for HIM-17 in regulating the balance between germ cell proliferation and meiotic development. A cryptic function for HIM-17 in promoting meiotic entry and/or inhibiting proliferation was revealed by defects in germline organization in him-17 mutants grown at high temperature (25 degrees) and by a synthetic tumorous germline phenotype in glp-1(ar202); him-17 mutants at 15 degrees.

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