The Caenorhabditis elegans Rad17 Homolog HPR-17 Is Required for Telomere Replication | Zendy

Julie Boerckel | Zendy; Dana Walker | Zendy; Shawn Ahmed | Zendy

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The Caenorhabditis elegans Rad17 Homolog HPR-17 Is Required for Telomere Replication

Author(s) -

Julie Boerckel,

Dana Walker,

Shawn Ahmed

Publication year - 2007

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.106.070201

Subject(s) - biology , telomere , caenorhabditis elegans , replication factor c , proliferating cell nuclear antigen , dna replication , telomerase , telomere binding protein , microbiology and biotechnology , dna damage , genetics , dna clamp , replication protein a , dna , eukaryotic dna replication , dna binding protein , gene , rna , reverse transcriptase , transcription factor

Subunits of the Rad9/Rad1/Hus1 (9-1-1) proliferating cell nuclear antigen (PNCA)-like sliding clamp are required for DNA damage responses and telomerase-mediated telomere replication in the nematode Caenorhabditis elegans. PCNA sliding clamps are loaded onto DNA by a replication factor C (RFC) clamp loader. The C. elegans Rad17 RFC clamp loader homolog, hpr-17, functions in the same pathway as the 9-1-1 complex with regard to both the DNA damage response and telomerase-mediated telomere elongation. Thus, hpr-17 defines an RFC-like complex that facilitates telomerase activity in vivo in C. elegans.

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