Survival Quantitative Trait Locus Fine Mapping by Measuring and Testing for Hardy–Weinberg and Linkage Disequilibrium | Zendy

J. Casellas | Zendy

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Survival Quantitative Trait Locus Fine Mapping by Measuring and Testing for Hardy–Weinberg and Linkage Disequilibrium

Author(s) -

J. Casellas

Publication year - 2007

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.106.067264

Subject(s) - linkage disequilibrium , biology , genetics , locus (genetics) , trait , disequilibrium , linkage (software) , quantitative trait locus , hardy–weinberg principle , allele frequency , allele , haplotype , gene , medicine , computer science , ophthalmology , programming language

I show that fine-scale localization of a survival-related locus can be accomplished on the basis of deviations from Hardy-Weinberg equilibrium and linkage disequilibrium at closely linked marker loci. The method is based on chi(2)-tests and they can be performed for age-specific samples of alive (or dead) individuals, as for combined samples of alive and dead individuals.

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