Bayesian Multiple Quantitative Trait Loci Mapping for Complex Traits Using Markers of the Entire Genome | Zendy

Hanwen Huang | Zendy; Chevonne D. Eversley | Zendy; David W. Threadgill | Zendy; Fei Zou | Zendy

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Bayesian Multiple Quantitative Trait Loci Mapping for Complex Traits Using Markers of the Entire Genome

Author(s) -

Hanwen Huang,

Chevonne D. Eversley,

David W. Threadgill,

Fei Zou

Publication year - 2007

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.106.064980

Subject(s) - biology , quantitative trait locus , genetics , trait , bayesian probability , genome , evolutionary biology , genome scan , computational biology , genome wide association study , genetic marker , allele , gene , microsatellite , statistics , single nucleotide polymorphism , genotype , mathematics , computer science , programming language

A Bayesian methodology has been developed for multiple quantitative trait loci (QTL) mapping of complex binary traits that follow liability threshold models. Unlike most QTL mapping methods where only one or a few markers are used at a time, the proposed method utilizes all markers across the genome simultaneously. The outperformance of our Bayesian method over the traditional single-marker analysis and interval mapping has been illustrated via simulations and real data analysis to identify candidate loci associated with colorectal cancer.

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