Deletion Polymorphism ofDisc1Is Common to All 129 Mouse Substrains: Implications for Gene-Targeting Studies of Brain Function | Zendy

Steven J. Clapcote | Zendy; John Roder | Zendy

Open Access

Deletion Polymorphism ofDisc1Is Common to All 129 Mouse Substrains: Implications for Gene-Targeting Studies of Brain Function

Author(s) -

Steven J. Clapcote,

John Roder

Publication year - 2006

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.106.060749

Subject(s) - biology , genetics , extant taxon , embryonic stem cell , gene , allele , knockout mouse , function (biology) , gene targeting , gene knockin , inbred strain , gene knockout , disc1 , evolutionary biology

We report that the Disc1 gene in all extant 129 mouse inbred substrains has a deletion, previously considered specific to the 129S6/SvEv substrain, which is predicted to abolish production of the full-length protein. This finding has implications for the study of knockout mice generated from 129-derived embryonic stem cells.

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