Loss-Of-Function Alleles of the JIL-1 Kinase Are Strong Suppressors of Position Effect Variegation of the wm4 Allele in Drosophila | Zendy

Stephanie Lerach | Zendy; Weiguo Zhang | Zendy; Xiaomin Bao | Zendy; Huai Deng | Zendy; Jack Girton | Zendy; Jørgen Johansen | Zendy; Kristen M. Johansen | Zendy

Open Access

Loss-Of-Function Alleles of the JIL-1 Kinase Are Strong Suppressors of Position Effect Variegation of the wm4 Allele in Drosophila

Author(s) -

Stephanie Lerach,

Weiguo Zhang,

Xiaomin Bao,

Huai Deng,

Jack Girton,

Jørgen Johansen,

Kristen M. Johansen

Publication year - 2006

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.106.059253

Subject(s) - allele , biology , genetics , function (biology) , drosophila melanogaster , drosophila (subgenus) , suppressor , loss function , position effect , variegation (histology) , gene , phenotype

In this article we show that hypomorphic loss-of-function alleles of the JIL-1 histone H3S10 kinase are strong suppressors of position effect variegation (PEV) of the wm4 allele and that lack of JIL-1 activity can counteract the effect of the dominant enhancer Evar2-1 on PEV.

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