Drosophila ATM and Mre11 Are Essential for the G2/M Checkpoint Induced by Low-Dose Irradiation | Zendy

Xiaolin Bi | Zendy; Min Gong | Zendy; Deepa Srikanta | Zendy; Yikang S. Rong | Zendy

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Drosophila ATM and Mre11 Are Essential for the G2/M Checkpoint Induced by Low-Dose Irradiation

Author(s) -

Xiaolin Bi,

Min Gong,

Deepa Srikanta,

Yikang S. Rong

Publication year - 2005

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.105.047720

Subject(s) - g2 m dna damage checkpoint , biology , chek1 , checkpoint kinase 2 , dna damage , mitosis , microbiology and biotechnology , cell cycle checkpoint , dna repair , function (biology) , genetics , kinase , regulator , dna , cancer research , protein kinase a , protein serine threonine kinases , cell cycle , gene

Others have suggested recently that the conserved ATM checkpoint kinase is minimally involved in controlling the G(2)/M checkpoint in Drosophila that serves to prevent mitotic entry in the presence of DNA damage. Our data indicate that both ATM and its regulator Mre11 are important for the checkpoint and that their roles become essential when animals are challenged with a low dose of X rays or when they have compromised checkpoint function of the ATM-related ATR kinase.

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