Directional Positive Selection on an Allele of Arbitrary Dominance | Zendy

Kosuke M. Teshima | Zendy; Molly Przeworski | Zendy

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Directional Positive Selection on an Allele of Arbitrary Dominance

Author(s) -

Kosuke M. Teshima,

Molly Przeworski

Publication year - 2005

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.105.044065

Subject(s) - biology , allele , dominance (genetics) , genetics , directional selection , fixation (population genetics) , selection (genetic algorithm) , coalescent theory , evolutionary biology , allele frequency , gene , genetic variation , phylogenetics , artificial intelligence , computer science

Most models of positive directional selection assume codominance of the beneficial allele. We examine the importance of this assumption by implementing a coalescent model of positive directional selection with arbitrary dominance. We find that, for a given mean fixation time, a beneficial allele has a much weaker effect on diversity at linked neutral sites when the allele is recessive.

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