Recombination and the Properties of Tajima's D in the Context of Approximate-Likelihood Calculation | Zendy

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Recombination and the Properties of Tajima's D in the Context of Approximate-Likelihood Calculation

Author(s) -

Kevin Thornton

Publication year - 2005

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.105.043786

Subject(s) - recombination , biology , inference , recombination rate , context (archaeology) , population genetics , maximum likelihood , population , genetics , evolutionary biology , statistics , gene , demography , mathematics , epistemology , sociology , paleontology , philosophy

I show that Tajima's D, a commonly used summary of the site-frequency spectrum for single-nucleotide polymorphism data, is a biased summary of the site-frequency spectrum. Under neutral models, this bias depends on the population recombination rate. This bias of D in summarizing the data makes inference of demographic parameters sensitive to assumptions about recombination rates.

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