The Course of Malaria in Mice: Major Histocompatibility Complex (MHC) Effects, but No General MHC Heterozygote Advantage in Single-Strain Infections | Zendy

Claus Wedekind | Zendy; Mirjam Walker | Zendy; Tom J. Little | Zendy

Open Access

The Course of Malaria in Mice: Major Histocompatibility Complex (MHC) Effects, but No General MHC Heterozygote Advantage in Single-Strain Infections

Author(s) -

Claus Wedekind,

Mirjam Walker,

Tom J. Little

Publication year - 2005

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.105.040683

Subject(s) - heterozygote advantage , biology , major histocompatibility complex , congenic , genetics , compound heterozygosity , malaria , parasite hosting , haplotype , phenotype , strain (injury) , immunology , immune system , allele , gene , anatomy , world wide web , computer science

A general MHC-heterozygote advantage in parasite-infected organisms is often assumed, although there is little experimental evidence for this. We tested the response of MHC-congenic mice (F2 segregants) to malaria and found the course of infection to be significantly influenced by MHC haplotype, parasite strain, and host gender. However, the MHC heterozygotes did worse than expected from the average response of the homozygotes.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research