Open AccessThe 2006 Genetics Society of America Medal
Author(s) -
Géraldine Seydoux
Publication year - 2006
Publication title -
genetics.
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.792
H-Index - 246
ISSN - 3049-7094
DOI - 10.1534/genetics.104.17222
Subject(s) - orfs , open reading frame , biology , genetics , fragment (logic) , gene , mutant , mutation , peptide sequence , computer science , programming language
In 1990, Victor Ambros faced a conundrum. The search for the heterochronic gene lin-4 had led him to a 700-bp DNA fragment. This fragment could rescue a lin-4 mutant but contained no apparent open reading frame (ORF). The few small ORFs that could be detected were either not conserved in other
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