Open AccessOn the Mutation Rate of Herpes Simplex Virus Type 1
Author(s) -
John W. Drake,
Charles B. C. Hwang
Publication year - 2005
Publication title -
genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.792
H-Index - 246
eISSN - 1943-2631
pISSN - 0016-6731
DOI - 10.1534/genetics.104.040410
Subject(s) - biology , mutation rate , herpes simplex virus , mutation , genetics , chromosome , mutation frequency , virology , dna , virus , genomic dna , viral replication , gene
All seven DNA-based microbes for which carefully established mutation rates and mutational spectra were previously available displayed a genomic mutation rate in the neighborhood of 0.003 per chromosome replication. The pathogenic mammalian DNA virus herpes simplex type 1 has an estimated genomic mutation rate compatible with that value.
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