Mapping a Syntenic Modifier on Mouse Chromosome 1 Influencing the Expressivity of the Compact Phenotype in the Myostatin Mutant (MstnCmpt-dl1Abc) Compact Mouse | Zendy

L. Varga | Zendy; O. Pinke | Zendy; Géza Müller | Zendy; Balázs Kovács | Zendy; Edit Korom | Zendy; Gyula Szabó | Zendy; M. Soller | Zendy

Open Access

Mapping a Syntenic Modifier on Mouse Chromosome 1 Influencing the Expressivity of the Compact Phenotype in the Myostatin Mutant (MstnCmpt-dl1Abc) Compact Mouse

Author(s) -

L. Varga,

O. Pinke,

Géza Müller,

Balázs Kovács,

Edit Korom,

Gyula Szabó,

M. Soller

Publication year - 2004

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.104.034033

Subject(s) - biology , genetics , phenotype , mutant , expressivity , synteny , chromosome , myostatin , mutagenesis , gene

A novel method for mapping a modifier gene that is syntenic to its major gene was used to map a male-sex-limited modifier of the expressivity of the Compact phenotype in the myostatin mutant (MstnCmpt-dl1Abc) Compact mouse. The modifier was mapped to the general region of D1Mit262, 40 cM distal to Mstn on chromosome 1. Myogenin, a postulated downstream target of myostatin, maps to the same region.

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