A Novel Yeast Mutation, rad52-L89F, Causes a Specific Defect in Rad51-Independent Recombination That Correlates With a Reduced Ability of Rad52-L89F to Interact With Rad59 | Zendy

Felipe CortésLedesma | Zendy; Francisco Malagón | Zendy; Andrés Aguilera | Zendy

Open Access

A Novel Yeast Mutation, rad52-L89F, Causes a Specific Defect in Rad51-Independent Recombination That Correlates With a Reduced Ability of Rad52-L89F to Interact With Rad59

Author(s) -

Felipe CortésLedesma,

Francisco Malagón,

Andrés Aguilera

Publication year - 2004

Publication title -

genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.792

H-Index - 246

eISSN - 1943-2631

pISSN - 0016-6731

DOI - 10.1534/genetics.104.030551

Subject(s) - rad52 , rad51 , homologous recombination , biology , ectopic recombination , genetics , recombination , mutation , flp frt recombination , mutant , genetic recombination , dna repair , homologous chromosome , phenotype , mitotic crossover , dna , gene

We isolated a novel rad52 mutation, rad52-L89F, which specifically impairs recombination in rad51Delta cells. rad52-L89F displays phenotypes similar to rad59Delta and encodes a mutant protein impaired in its ability to interact with Rad59. These results support the idea that Rad59 acts in homologous recombination via physical interaction with Rad52.

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