Open AccessGene Dosage Balance in Cellular Pathways
Author(s) -
Reiner A. Veitia
Publication year - 2004
Publication title -
genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.792
H-Index - 246
eISSN - 1943-2631
pISSN - 0016-6731
DOI - 10.1534/genetics.104.029785
Subject(s) - biology , gene dosage , balance (ability) , genetics , gene , phenotype , gene expression , neuroscience
THE gene dosage balance hypothesis (GDBH) proposes, in a narrow sense, that stoichiometric imbalances in macromolecular complexes can be a source of dominant phenotypes. Gene dosage balance in such complexes is required as a “here and now” condition, as a partial aneuploid carrying a deletion or
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